Monday 18 July 2016 | 77

A gathering for mice !

A gathering for mice !

Mis à jour le 28 April 2019

While manufacturers of botulinum toxin are committed to no longer using the LD50 test, a Japanese firm continues to sacrifice mice on masse. One Voice and Doctors against Animal Experiments are mobilizing !

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Since 2010 One Voice has campaigned for mice killed in large numbers in laboratories (see the history of its actions for the abolition of animal experimentation). The case of those sacrificed for the production of botulinum toxin is particularly cruel. The LD50 (or median lethal dose) test is performed for each batch of toxin to determine the dose that will kill 50% of the mice. The substance is injected into the abdomen, causing them intolerable suffering. Gradually paralyzed, they finally die by suffocation.

In 2011 the Allergan laboratory, the American manufacturer of Botox®, announced that it had found an in vitro method for the development of its product, signing a first victory for the European campaign led by the ECEAE, of which One Voice is the representative for France. Its direct competitors, IPSEN and Merz, have recently followed suit, although validation procedures are still in progress. Only a Japanese firm is still reluctant to give up using mice ...

Eisai is a Japanese laboratory. It sells in Europe Neurobloc®, a botulinum toxin type B drug. Initially intended for the treatment of torticollis, its use is spreading today among those whose wrinkles have become resistant to botulinum toxin type A the competition ... According to our sources, the German laboratory LPT, which carries out the tests for its account in Europe, was authorized to carry out the LD50 on 60,000 mice in 2014! And if Eisai declares that a replacement procedure is being studied, how many will still be tortured before the final analysis? Let's mobilize for an immediate stop of the sacrifice of these mice !

Action for the mice

One Voice and Doctors against Animal Experiments, its German partner in the ECEAE, launches a pressure campaign on Eisai.

  • Write to their representative in France !


Eisai SAS

5/6, Place de l'Iris

Manhattan Tower

92095 La Defense


You will find below the text we recommend you to use:

Dear Sir or Madam,

I am horrified to learn that your firm is commissioning the LPT contract laboratory to do tests using LD50 your NeuroBloc® product with botulinum toxin B. In 2014, no less than 60,000 mice have been killed!

Other manufacturers have already abandoned animal testing in favour of methods using human cells.

Therefore, I ask you to immediately stop the LD50 tests on mice and replace it with an ethical alternative, one without animals.




  • Support the actions of One Voice for the abolition of animal experimentation !
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In the subject

Animal testing: investigation from One Voice in Mauritius into long-tailed macaque breeding farms 'Monkeys Labs': from condoned mistreatment, proven trafficking, and health risks

Comments 77

I accept that publication of my comments is subject to the code of conduct.

Ticia | Tuesday 18 May 2021

Madame, Monsieur,

Je suis horrifié(e) d'apprendre que votre firme charge le laboratoire contractuel LPT d'expérimenter sur des souris, au moyen du test de la DL50, votre produit NeuroBloc® de toxine botulique B. Rien qu'en 2014, pas moins de 60.000 souris en ont ainsi été victimes !

D'autres fabricants ont déjà abandonné les tests sur les animaux au profit de méthodes utilisant des cellules humaines.

Par conséquent, je vous demande l'arrêt immédiat de la DL50 sur les souris et son remplacement par une alternative éthique, sans animaux.


Patricia Nong

pascale | Monday 07 August 2017

stop a la barbarie grrrrrrrrrrrrr

dasogo | Saturday 03 September 2016

Il faut arrêter de torturer ces pauvres bêtes, il y en a marre de cette souffrance au nom de la science.

mme Gogibus Sonia

JACOB | Friday 29 July 2016

Mail envoyé, en espérant que cela servira la cause des animaux