Thursday 05 July 2018 | 8

The scandal of Dépakine (Thalidomide): Animal experiments prove again to be dangerous

The scandal of Dépakine (Thalidomide): Animal experiments prove again to be dangerous

Mis à jour le 30 July 2018

Tens of thousands of children have been born with early neurodevelopmental disorders, victims of the effects of Depakine, taken by their mothers during pregnancy. Depakine, such as Thalidomide and Distilbene have however been tested on animals before they were placed on the market, as required by current regulations. How many human and nonhuman people will still have to be victims of the obsolete, cruel and dangerous procedures of animal testing?

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Tens of thousands of victims, human and animal

How many thousands of animals have been sacrificed? How many mothers of monkeys, rats and rabbits who have been injected with teratogen products, that is to say likely to alter ineluctably the development in utero of their young? How many babies, who as soon as they were born or snatched from the womb, were euthanized and underwent autopsies?

No, it is not a blessing in disguise, it is a frightful evil for another evil, which is just as bad.

After Thalidomide and Distilbène, Dépakine is the new health related outrage. Indeed, these three drugs have been tested on animals, including during pregnancy. Animals have been killed so that these substances can be sold. But this could not prevent the disasters related to their use by pregnant women.

The biggest scandal was that of Thalidomide in the early 1960s: 10,000 births with very serious malformations (absence of limbs, damaged organs) which caused some babies’ death. In the case of Distilbene (whose harmful effects were discovered in the early 1970s), children and even grandchildren of mothers who took this drug, were born with reproductive system pathologies, including cervical cancer. 

The toxic effects of depakine on the fetus

Depakine is an antiepileptic medicine marketed in France since 1967. It has been recognized as causing malformations and developmental delays in exposed children during pregnancy.

The first case of malformations suspected to have been caused by Depakine dates back to 1980. Yet it took twenty-six years for the Ministry of Health to advise against its use by pregnant women. By the end of 2017, the laboratory's responsibility has been established. Last June, the number of children with neurological disorders (including autism and mental retardation), after being exposed to Depakine, was estimated between 16,600 and 30,400!

Animal experimentation is worse than unsuitable, it is dangerous!

According to our scientific team, animal testing does not make it possible to obtain the certainty of the safety of a drug, especially during pregnancy. Gestations between humans and animals are not comparable: the embryonic and foetal phases are organized differently over time. In the case of Depakine, the human embryo develops skeletal malformations at much lower doses than animals.

But if animal testing cannot confirm a safe dosage to avoid such obvious effects, how can one still believe that they can help identify more nuanced effects, such as autism and developmental delays?

Towards modern science

We are undoubtedly living in an age where scientific knowledge is the most advanced in the whole history of mankind. But paradoxically, we do not know how to apply them intelligently! How many health disasters must we endure to ensure that the reliability of animal testing is finally called into question? Persisting to resort in using species that are separate from us as a reference is a nonsense which must not be continued for both animals and for us.

Hr blog

In the subject

Animal testing: investigation from One Voice in Mauritius into long-tailed macaque breeding farms 'Monkeys Labs': from condoned mistreatment, proven trafficking, and health risks

Comments 8

I accept that publication of my comments is subject to the code of conduct.

Joey | Thursday 05 July 2018

Il aime juste faire du mal

mumu | Thursday 05 July 2018

on n'est plus au 18ème siècle ! l'expérimentation sur animaux doit être abolie, de quel droit serions-nous , humains, supérieurs et habilités à faire souffrir ?

anne | Thursday 05 July 2018

L'expérimentation sur l'animal rend la médecine actuelle aussi ridicule et dangereuse que celle, tant moquée de temps révolus, où tout se traitant à coups de clystères et de poudre de coléoptère, tout simplement parce qu'un certain Darwin a compris la barrière des espèces.
Autrement dit: nous ne sommes pas des rats de 70 kg.
Un jour,on rira de notre obscurantisme.

trochu | Thursday 05 July 2018

J'ai toujours été très choquée, très révoltée et très attristée par le nombre incroyable et inimaginable d'animaux torturés et tués pour la recherche médicale, et étant militante de toujours pour la cause animale dans tous domaines (qui est et sera toujours mon combat de vie) je trouve ahurissant et plus que honteux que les animaux soient encore utilisés comme matériel de recherche. Nous avons tous les jours la preuve bien réelle que l'expérimentation sur des pauvres animaux ne sert absolument à rien vu le nombre de médicaments constamment retirés du marché alors qu'ils ont tous été testés sur des animaux, et sont très nocifs et dangereux pour l'humain. Quand donc tous ces chercheurs ouvriront leurs yeux et surtout leurs consciences et leurs coeurs, en reconnaissant que toutes ces cruautés envers d'autres êtres sensibles doivent cesser à jamais au profit des méthodes alternatives qui sont éthiques et fiables ?
Je me demande s'il ne serait pas possible de mener des campagnes de récolte de dons en faveur d'une recherche scientifique éthique en expliquant et informant clairement les personnes, nous serions peut-être très étonnés de voir à quel point les gens sont encore très ignorants et mal informés sur ce grave sujet qu'est l'expérimentation animale. MERCI BEAUCOUP ONE VOICE de dénoncer au grand jour l'inefficacité et la dangerosité de l'expérimentation animale qui doit être abolie définitivement si notre société veut se prétendre "grande, belle avec valeurs morales et du civisme"....