Thursday 05 July 2018 | 8

The scandal of Dépakine (Thalidomide): Animal experiments prove again to be dangerous

Tens of thousands of children have been born with early neurodevelopmental disorders, victims of the effects of Depakine, taken by their mothers during pregnancy. Depakine, such as Thalidomide and Distilbene have however been tested on animals before they were placed on the market, as required by current regulations. How many human and nonhuman people will still have to be victims of the obsolete, cruel and dangerous procedures of animal testing?

Hr blog

Tens of thousands of victims, human and animal

How many thousands of animals have been sacrificed? How many mothers of monkeys, rats and rabbits who have been injected with teratogen products, that is to say likely to alter ineluctably the development in utero of their young? How many babies, who as soon as they were born or snatched from the womb, were euthanized and underwent autopsies?

No, it is not a blessing in disguise, it is a frightful evil for another evil, which is just as bad.

After Thalidomide and Distilbène, Dépakine is the new health related outrage. Indeed, these three drugs have been tested on animals, including during pregnancy. Animals have been killed so that these substances can be sold. But this could not prevent the disasters related to their use by pregnant women.

The biggest scandal was that of Thalidomide in the early 1960s: 10,000 births with very serious malformations (absence of limbs, damaged organs) which caused some babies’ death. In the case of Distilbene (whose harmful effects were discovered in the early 1970s), children and even grandchildren of mothers who took this drug, were born with reproductive system pathologies, including cervical cancer. 

The toxic effects of depakine on the fetus

Depakine is an antiepileptic medicine marketed in France since 1967. It has been recognized as causing malformations and developmental delays in exposed children during pregnancy.

The first case of malformations suspected to have been caused by Depakine dates back to 1980. Yet it took twenty-six years for the Ministry of Health to advise against its use by pregnant women. By the end of 2017, the laboratory's responsibility has been established. Last June, the number of children with neurological disorders (including autism and mental retardation), after being exposed to Depakine, was estimated between 16,600 and 30,400!

Animal experimentation is worse than unsuitable, it is dangerous!

According to our scientific team, animal testing does not make it possible to obtain the certainty of the safety of a drug, especially during pregnancy. Gestations between humans and animals are not comparable: the embryonic and foetal phases are organized differently over time. In the case of Depakine, the human embryo develops skeletal malformations at much lower doses than animals.

But if animal testing cannot confirm a safe dosage to avoid such obvious effects, how can one still believe that they can help identify more nuanced effects, such as autism and developmental delays?

Towards modern science

We are undoubtedly living in an age where scientific knowledge is the most advanced in the whole history of mankind. But paradoxically, we do not know how to apply them intelligently! How many health disasters must we endure to ensure that the reliability of animal testing is finally called into question? Persisting to resort in using species that are separate from us as a reference is a nonsense which must not be continued for both animals and for us.

Hr blog

In the subject

In Turin, macaques blinded by continuous brain operations
Experimentation: well done with the figures, nothing has changed!

Comments 8

I accept that publication of my comments is subject to the code of conduct.

C AM | Tuesday 18 September 2018

Stop à l'expérimentation animale inutile et cruelle et indigne

jesuismoi | Tuesday 24 July 2018

La course à la croissance et à la consommation pousse à l'expérimentation animale.Toutes les industries utilisent la vivisection : pharmacie, armée,cosmétique, industrie etc...

trochu | Monday 09 July 2018

Le respect de la vie et de toute vie doit être appliqué autant pour les humains que pour les animaux qui sont je le rappelle, DES ETRES VIVANTS à part entière comme nous, avec les mêmes besoins que nous et les mêmes facultés mentales que nous à des degrés différents mais non "inférieurs" et ils méritent donc tous, le même très grand respect et considération que nous cela devrait ressembler à de l'évidence ! Les animaux ne sont pas "des objets multiples, des outils ou matériel de recherche" et le fait de les arracher brutalement à leurs habitats naturels, aux leurs, à leur très chère liberté, de les emprisonner, les maltraiter à l'extrême, les torturer, commettre les pires des atrocités inimaginables à leurs encontre, les mutiler et les tuer dans la souffrance et la douleur honteuse et inacceptable, est un crime grave et scandaleux. De quel droit sacrifier la vie de tous ces malheureux animaux pour sauver la nôtre ? Une vie est une vie et la vie des animaux a autant de valeur, d'importance que la nôtre. L'expérimentation animale doit être absolument abolie définitivement, car d'une part ne sert à rien si ce n'est à enrichir les laboratoires qui s'en mettent plein les poches sur le dos de ces êtres vivants, et d'autre part, il y a constamment des médicaments qui sont retirés du marché car "nocifs, très dangereux, trop d'effets secondaires," pour les humains, sans parler du nombre de personnes décédées et qui décèdent encore suit à des traitements qui ont pourtant été testés. Il est très important de plébisciter les méthodes alternatives et de substitution les seules à être ETHIQUES ET FIABLES, et les populations doivent être sensibilisées et informées.

lea | Saturday 07 July 2018

lamentable !ces pseudo laboratoire qui vendent et s enrichisse a nous filant leur saletés!Peut importe la souffrance de leur cobayes peu importe les conséquences .